A highly selective fluorogenic probe for the detection and in vivo imaging of Cu/Zn superoxide dismutase.
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ABSTRACT:
SUBMITTER: Zhang L
PROVIDER: S-EPMC4943070 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Publications
A highly selective fluorogenic probe for the detection and in vivo imaging of Cu/Zn superoxide dismutase.
Zhang Liyun L Er Jun Cheng JC Jiang Hao H Li Xin X Luo Zhaofeng Z Ramezani Thomas T Feng Yi Y Tang Mui Kee MK Chang Young-Tae YT Vendrell Marc M
Chemical communications (Cambridge, England) 20160701 58
Copper/zinc superoxide dismutase (Cu/Zn SOD) is an essential enzyme that protects tissue from oxidative damage. Herein we report the first fluorogenic probe (SODO) for the detection and in vivo imaging of Cu/Zn SOD. SODO represents a unique chemical probe for translational imaging studies of Cu/Zn SOD in inflammatory disorders. ...[more]
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