Ontology highlight
ABSTRACT:
SUBMITTER: Modena A
PROVIDER: S-EPMC4943092 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Modena Alessandra A Ciccarese Chiara C Iacovelli Roberto R Brunelli Matteo M Montironi Rodolfo R Fiorentino Michelangelo M Tortora Giampaolo G Massari Francesco F
Oncology reviews 20160415 1
Despite recent advances in the treatment of metastatic castration-resistant prostate cancer (mCRPC), agents that provide durable disease control and long-term survival are still needed. It is a fact that a tumor-induced immunosuppressive status (mediated by aberrant activation of inhibitory immune checkpoint pathways as a mechanism to evade host immune surveillance) plays a crucial role in the pathogenesis of cancer, including prostate cancer (PC), making CRPC patients suitable candidates for im ...[more]