The Unicellular Ancestry of Groucho-Mediated Repression and the Origins of Metazoan Transcription Factors.

ABSTRACT: Groucho is a co-repressor that interacts with many transcription factors playing a crucial role in animal development. The evolutionary origins of Groucho are not clear. It is generally regarded as being a distinct animal-specific protein, although with similarities to the yeast Tup-like proteins. Here, it is shown that Groucho has true orthologs in unicellular relatives of animals. Based on their phylogenetic distribution, and an analysis of ligand-binding residues, these genes are unlikely to be orthologs of the fungal Tup-like genes. By identifying conserved candidate Groucho interaction motifs (GIMs) in nonmetazoan transcription factors, it is demonstrated that the details of molecular interactions between Groucho and transcription factors are likely to have been established prior to t

SUBMITTER: Copley RR 

PROVIDER: S-EPMC4943189 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature