Mendelian Randomization - the Key to Understanding Aspects of Parkinson's Disease Causation?
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ABSTRACT:
SUBMITTER: Noyce AJ
PROVIDER: S-EPMC4943230 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
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Mendelian Randomization - the Key to Understanding Aspects of Parkinson's Disease Causation?
Noyce Alastair J AJ Nalls Mike A MA
Movement disorders : official journal of the Movement Disorder Society 20151223 4
Parkinson's disease has multiple determinants and is associated with a wide range of exposures that appear to modify risk in traditional observational studies, including numerous lifestyle and environmental factors. Across other fields of medicine, Mendelian randomization has emerged as a powerful method to examine whether associations between exposures and disease outcomes are causal. Here we discuss the concept of Mendelian randomization, its potential relevance to Parkinson's disease, and sug ...[more]
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