Ontology highlight
ABSTRACT:
SUBMITTER: Nowosad CR
PROVIDER: S-EPMC4943528 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Nature immunology 20160516 7
B cell activation is regulated by B cell antigen receptor (BCR) signaling and antigen internalization in immune synapses. Using large-scale imaging across B cell subsets, we found that, in contrast with naive and memory B cells, which gathered antigen toward the synapse center before internalization, germinal center (GC) B cells extracted antigen by a distinct pathway using small peripheral clusters. Both naive and GC B cell synapses required proximal BCR signaling, but GC cells signaled less th ...[more]