Molecular Drivers of the Non-T-cell-Inflamed Tumor Microenvironment in Urothelial Bladder Cancer.
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ABSTRACT:
SUBMITTER: Sweis RF
PROVIDER: S-EPMC4943758 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Publications
Molecular Drivers of the Non-T-cell-Inflamed Tumor Microenvironment in Urothelial Bladder Cancer.
Sweis Randy F RF Spranger Stefani S Bao Riyue R Paner Gladell P GP Stadler Walter M WM Steinberg Gary G Gajewski Thomas F TF
Cancer immunology research 20160517 7
Muscle-invasive urothelial bladder cancer is a common malignancy with poor outcomes for which immune checkpoint blockade is now showing promise. Despite clinical activity of PD-1/PD-L1-targeted therapy in this disease, most patients do not benefit and resistance mechanisms remain unknown. The non-T-cell-inflamed tumor microenvironment correlates with poor prognosis and resistance to immunotherapies. In this study, we determined tumor-oncogenic pathways correlating with T-cell exclusion. We first ...[more]
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