Ontology highlight
ABSTRACT:
SUBMITTER: Zhao WL
PROVIDER: S-EPMC4944123 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Zhao Wen-Li WL Wang Di D Liu Chun-Yan CY Zhao Xiao-Fan XF
Scientific reports 20160714
G-protein-coupled receptors (GPCRs) transmit extracellular signals across the cell membrane. GPCR kinases (GRKs) desensitize GPCR signals in the cell membrane. However, the role and mechanism of GRKs in the desensitization of steroid hormone signaling are unclear. In this study, we propose that GRK2 is phosphorylated by protein kinase C (PKC) in response to induction by the steroid hormone 20-hydroxyecdysone (20E), which determines its translocation to the cell membrane of the lepidopteran Helic ...[more]