Ontology highlight
ABSTRACT:
SUBMITTER: Saul L
PROVIDER: S-EPMC4944184 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Saul Louise L Ilieva Kristina M KM Bax Heather J HJ Karagiannis Panagiotis P Correa Isabel I Rodriguez-Hernandez Irene I Josephs Debra H DH Tosi Isabella I Egbuniwe Isioma U IU Lombardi Sara S Crescioli Silvia S Hobbs Carl C Villanova Federica F Cheung Anthony A Geh Jenny L C JL Healy Ciaran C Harries Mark M Sanz-Moreno Victoria V Fear David J DJ Spicer James F JF Lacy Katie E KE Nestle Frank O FO Karagiannis Sophia N SN
Scientific reports 20160714
B cells participate in immune surveillance in human circulation and tissues, including tumors such as melanoma. By contrast, the role of humoral responses in cutaneous immunity is underappreciated. We report circulating skin-homing CD22+CLA+B cells in healthy volunteers and melanoma patients (n = 73) and CD22+ cells in melanoma and normal skin samples (n = 189). Normal and malignant skin featured mature IgG and CD22 mRNA, alongside mRNA for the transiently-expressed enzyme Activation-induced cyt ...[more]