Ontology highlight
ABSTRACT:
SUBMITTER: Nakagomi H
PROVIDER: S-EPMC4944198 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Nakagomi Hiroshi H Yoshiyama Mitsuharu M Mochizuki Tsutomu T Miyamoto Tatsuya T Komatsu Ryohei R Imura Yoshio Y Morizawa Yosuke Y Hiasa Miki M Miyaji Takaaki T Kira Satoru S Araki Isao I Fujishita Kayoko K Shibata Keisuke K Shigetomi Eiji E Shinozaki Youichi Y Ichikawa Reiko R Uneyama Hisayuki H Iwatsuki Ken K Nomura Masatoshi M de Groat William C WC Moriyama Yoshinori Y Takeda Masayuki M Koizumi Schuichi S
Scientific reports 20160714
The bladder urothelium is more than just a barrier. When the bladder is distended, the urothelium functions as a sensor to initiate the voiding reflex, during which it releases ATP via multiple mechanisms. However, the mechanisms underlying this ATP release in response to the various stretch stimuli caused by bladder filling remain largely unknown. Therefore, the aim of this study was to elucidate these mechanisms. By comparing vesicular nucleotide transporter (VNUT)-deficient and wild-type male ...[more]