Ontology highlight
ABSTRACT:
SUBMITTER: Wu W
PROVIDER: S-EPMC4944649 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
European journal of immunology 20160224 5
It has been shown that while commensal bacteria promote Th1, Th17 and Treg cells in lamina propria (LP) in steady-state conditions, they suppress mucosal Th2 cells. However, it is still unclear whether there are specific commensal organisms down-regulating Th2 responses, and the mechanism involved. Here we demonstrate that commensal A4 bacteria, a member of the Lachnospiraceae family, which produce an immunodominant microbiota CBir1 antigen, inhibits LP Th2-cell development. When transferred int ...[more]