Ontology highlight
ABSTRACT:
SUBMITTER: Lathrop SP
PROVIDER: S-EPMC4944760 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20160614 24
The first biomimetic enantioselective total synthesis of (-)-communesin F based on a late-stage heterodimerization and aminal exchange is described. Our synthesis features the expedient diazene-directed assembly of two advanced fragments to secure the congested C3a-C3a' linkage in three steps, followed by a highly efficient biogenetically inspired aminal reorganization to access the heptacyclic communesin core in only two additional steps. Enantioselective syntheses of the two fragments were dev ...[more]