Ontology highlight
ABSTRACT:
SUBMITTER: Obradovic D
PROVIDER: S-EPMC4945079 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Obradović Davor D Gašperšič Rok R Caserman Simon S Leonardi Adrijana A Jamnik Maja M Podlesek Zdravko Z Seme Katja K Anderluh Gregor G Križaj Igor I Maček Peter P Butala Matej M
PloS one 20160714 7
The periodontopathogen Aggregatibacter actinomycetemcomitans synthesizes several virulence factors, including cytolethal distending toxin (CDT). The active CDT holoenzyme is an AB-type tripartite genotoxin that affects eukaryotic cells. Subunits CdtA and CdtC (B-components) allow binding and intracellular translocation of the active CdtB (A-component), which elicits nuclear DNA damage. Different strains of A. actinomycetemcomitans have diverse virulence genotypes, which results in varied pathoge ...[more]