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DNA-catalyzed glycosylation using aryl glycoside donors.

ABSTRACT: We report the identification by in vitro selection of Zn(2+)/Mn(2+)-dependent deoxyribozymes that glycosylate the 3'-OH of a DNA oligonucleotide. Both ? and ? anomers of aryl glycosides can be used as the glycosyl donors. Individual deoxyribozymes are each specific for a particular donor anomer.

SUBMITTER: Hesser AR

PROVIDER: S-EPMC4945402 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature

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DNA-catalyzed glycosylation using aryl glycoside donors.

Hesser Anthony R AR Brandsen Benjamin M BM Walsh Shannon M SM Wang Puzhou P Silverman Scott K SK

Chemical communications (Cambridge, England) 20160629 59

We report the identification by in vitro selection of Zn(2+)/Mn(2+)-dependent deoxyribozymes that glycosylate the 3'-OH of a DNA oligonucleotide. Both β and α anomers of aryl glycosides can be used as the glycosyl donors. Individual deoxyribozymes are each specific for a particular donor anomer. ...[more]

PMID: 27355482

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