Ontology highlight
ABSTRACT:
SUBMITTER: Kelly LK
PROVIDER: S-EPMC4945453 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Cell reports 20160623 2
Epithelial tissues are polarized along two axes. In addition to apical-basal polarity, they are often polarized within the plane of the epithelium, so-called Planar Cell Polarity (PCP). PCP depends upon Wnt/Frizzled (Fz) signaling factors, including Fz itself and Van Gogh (Vang/Vangl). We sought to understand how Vang interaction with other core PCP factors affects Vang function. We find that Fz induces Vang phosphorylation in a cell-autonomous manner. Vang phosphorylation occurs on conserved N- ...[more]