Ontology highlight
ABSTRACT:
SUBMITTER: Li X
PROVIDER: S-EPMC4946253 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Li Xu X Wang Wenqi W Xi Yuanxin Y Gao Min M Tran MyKim M Aziz Kathryn E KE Qin Jun J Li Wei W Chen Junjie J
Cell reports 20160623 2
By combining the results of a large-scale proteomic analysis of the human transcription factor interaction network with knowledge databases, we identified FOXR2 as one of the top-ranked candidate proto-oncogenes. Here, we show that FOXR2 forms a stable complex with MYC and MAX and subsequently regulates cell proliferation by promoting MYC's transcriptional activities. We demonstrate that FOXR2 is highly expressed in several breast, lung, and liver cancer cell lines and related patient tumor samp ...[more]