Ontology highlight
ABSTRACT:
SUBMITTER: Kim H
PROVIDER: S-EPMC4946366 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Kim Haeyoung H Cho Dae-Yeon DY Choi Doo Ho DH Jung Gee Hue GH Shin Inkyung I Park Won W Huh Seung Jae SJ Nam Seok Jin SJ Lee Jeong Eon JE Gil Won Ho WH Kim Seok Won SW
Cancer research and treatment 20160119 3
<h4>Purpose</h4>The aim of the current study is to assess the spectrum of genetic variation in the BRIP1 gene among Korean high-risk breast cancer patients who tested negative for the BRCA1/2 mutation.<h4>Materials and methods</h4>Overall, 235 Korean patientswith BRCA1/2 mutation-negative high-risk breast cancerwere screened for BRIP1 mutations. The entire BRIP1 gene was analyzed using fluorescent-conformation sensitive gel electrophoresis. In silico analysis of BRIP1 variants was performed usin ...[more]