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From hepatoprotection models to new therapeutic modalities for treating liver diseases: a personal perspective.

ABSTRACT: A variety of rodent models of hepatoprotection have been developed in which tolerance to acetaminophen-induced hepatotoxicity occurs. Autoprotection/heteroprotection is a phenomenon where prior exposure to a mildly toxic dose of toxicant confers protection against a subsequently administered higher dose of the same toxicant (as in the case of autoprotection) or to a different toxicant (referred to as heteroprotection). Multiple mechanisms regulate this adaptive response, including hepatocellular proliferation, proteostasis, enhanced expression of cytoprotective genes, and altered tissue immune response. In this review, we will discuss recent findings that highlight the complexity of these adaptive mechanisms and we also outline the usefulness of these findings to devise therapeutic and/or diagnostic tools for acetaminophen-induced liver damage in patients.

SUBMITTER: Rudraiah S

PROVIDER: S-EPMC4946394 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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From hepatoprotection models to new therapeutic modalities for treating liver diseases: a personal perspective.

Rudraiah Swetha S Manautou José E JE

F1000Research 20160714

A variety of rodent models of hepatoprotection have been developed in which tolerance to acetaminophen-induced hepatotoxicity occurs. Autoprotection/heteroprotection is a phenomenon where prior exposure to a mildly toxic dose of toxicant confers protection against a subsequently administered higher dose of the same toxicant (as in the case of autoprotection) or to a different toxicant (referred to as heteroprotection). Multiple mechanisms regulate this adaptive response, including hepatocellular ...[more]

PMID: 27499850

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Dataset Information

From hepatoprotection models to new therapeutic modalities for treating liver diseases: a personal perspective.

Publications

From hepatoprotection models to new therapeutic modalities for treating liver diseases: a personal perspective.

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