Ontology highlight
ABSTRACT:
SUBMITTER: Devlin R
PROVIDER: S-EPMC4946898 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Devlin Rebecca R Marques Catarina A CA Paape Daniel D Prorocic Marko M Zurita-Leal Andrea C AC Campbell Samantha J SJ Lapsley Craig C Dickens Nicholas N McCulloch Richard R
eLife 20160526
Survival of Trypanosoma brucei depends upon switches in its protective Variant Surface Glycoprotein (VSG) coat by antigenic variation. VSG switching occurs by frequent homologous recombination, which is thought to require locus-specific initiation. Here, we show that a RecQ helicase, RECQ2, acts to repair DNA breaks, including in the telomeric site of VSG expression. Despite this, RECQ2 loss does not impair antigenic variation, but causes increased VSG switching by recombination, arguing against ...[more]