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Applying amide proton transfer-weighted MRI to distinguish pseudoprogression from true progression in malignant gliomas.

ABSTRACT: To assess amide proton transfer-weighted (APTW) imaging features in patients with malignant gliomas after chemoradiation and the diagnostic performance of APT imaging for distinguishing true progression from pseudoprogression.After approval by the Institutional Review Board, 32 patients with clinically suspected tumor progression in the first 3 months after chemoradiation were enrolled and scanned at 3T. Longitudinal routine magnetic resonance imaging (MRI) changes and medical records were assessed to confirm true progression versus pseudoprogression. True progression was defined as lesions progressing on serial imaging over 6 months, and pseudoprogression was defined as lesions stabilizing or regressing without intervention. The APTWmean and APTWmax signals were obtained from three to five regions of interests for each patient and compared between the true progression and pseudoprogression groups. The diagnostic performance was assessed with receiver operating characteristic curve analysis.The true progression was associated with APTW hyperintensity (APTWmean ?=?2.75%?±?0.42%), while pseudoprogression was associated with APTW isointensity to mild hyperintensity (APTWmean ?=?1.56%?±?0.42%). The APTW signal intensities were significantly higher in the true progression group (n?=?20) than in the pseudoprogression group (P < 0.001; n?=?12). The cutoff APTWmean and APTWmax intensity values to distinguish between true progression and pseudoprogression were 2.42% (with a sensitivity of 85.0% and a specificity of 100%) and 2.54% (with a sensitivity of 95.0% and a specificity of 91.7%), respectively.The APTW-MRI signal is a valuable imaging biomarker for distinguishing pseudoprogression from true progression in glioma patients. J. Magn. Reson. Imaging 2016;44:456-462.

SUBMITTER: Ma B

PROVIDER: S-EPMC4946988 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature

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Applying amide proton transfer-weighted MRI to distinguish pseudoprogression from true progression in malignant gliomas.

Ma Bo B Blakeley Jaishri O JO Hong Xiaohua X Zhang Hongyan H Jiang Shanshan S Blair Lindsay L Zhang Yi Y Heo Hye-Young HY Zhang Mingzhi M van Zijl Peter C M PC Zhou Jinyuan J

Journal of magnetic resonance imaging : JMRI 20160120 2

<h4>Purpose</h4>To assess amide proton transfer-weighted (APTW) imaging features in patients with malignant gliomas after chemoradiation and the diagnostic performance of APT imaging for distinguishing true progression from pseudoprogression.<h4>Materials and methods</h4>After approval by the Institutional Review Board, 32 patients with clinically suspected tumor progression in the first 3 months after chemoradiation were enrolled and scanned at 3T. Longitudinal routine magnetic resonance imagin ...[more]

PMID: 26788865

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Project description:PurposeRadiological assessment of primary brain neoplasms, both high (HGG) and low grade tumors (LGG), based on contrast-enhancement alone can be inaccurate. We evaluated the radiological value of amide proton transfer weighted (APTw) MRI as an imaging complement for pre-surgical radiological diagnosis of brain tumors.MethodsTwenty-six patients were evaluated prospectively; (22 males, 4 females, mean age 55 years, range 26-76 years) underwent MRI at 3T using T1-MPRAGE pre- and post-contrast administration, conventional T2w, FLAIR, and APTw imaging pre-surgically for suspected primary/secondary brain tumor. Assessment of the additional value of APTw imaging compared to conventional MRI for correct pre-surgical brain tumor diagnosis. The initial radiological pre-operative diagnosis was based on the conventional contrast-enhanced MR images. The range, minimum, maximum, and mean APTw signals were evaluated. Conventional normality testing was performed; with boxplots/outliers/skewness/kurtosis and a Shapiro-Wilk's test. Mann-Whitney U for analysis of significance for mean/max/min and range APTw signal. A logistic regression model was constructed for mean, max, range and Receiver Operating Characteristic (ROC) curves calculated for individual and combined APTw signals.ResultsConventional radiological diagnosis prior to surgery/biopsy was HGG (8 patients), LGG (12 patients), and metastasis (6 patients). Using the mean and maximum: APTw signal would have changed the pre-operative evaluation the diagnosis in 8 of 22 patients (two LGGs excluded, two METs excluded). Using a cut off value of >2.0% for mean APTw signal integral, 4 of the 12 radiologically suspected LGG would have been diagnosed as high grade glioma, which was confirmed by histopathological diagnosis. APTw mean of >2.0% and max >2.48% outperformed four separate clinical radiological assessments of tumor type, P-values = .004 and = .002, respectively.ConclusionsUsing APTw-images as part of the daily clinical pre-operative radiological evaluation may improve diagnostic precision in differentiating LGGs from HGGs, with potential improvement of patient management and treatment.

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Applying amide proton transfer-weighted MRI to distinguish pseudoprogression from true progression in malignant gliomas.

Publications

Applying amide proton transfer-weighted MRI to distinguish pseudoprogression from true progression in malignant gliomas.

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