Ontology highlight
ABSTRACT:
SUBMITTER: Kato K
PROVIDER: S-EPMC4947182 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Kato Kazuki K Satouh Yuhkoh Y Nishimasu Hiroshi H Kurabayashi Arisa A Morita Junko J Fujihara Yoshitaka Y Oji Asami A Ishitani Ryuichiro R Ikawa Masahito M Nureki Osamu O
Nature communications 20160715
Sperm-egg fusion is the critical step in mammalian fertilization, and requires the interaction between IZUMO1 on the sperm surface and JUNO (also known as folate receptor (FR) 4 or IZUMO1R) on the egg surface. Whereas other FRs bind and uptake folates, JUNO binds IZUMO1 and establishes the cell-cell adhesion. However, the mechanism of IZUMO1 recognition by JUNO has remained elusive. Here we report the crystal structure of mouse JUNO, at 2.3 Å resolution. A structural comparison of JUNO with the ...[more]