Ontology highlight
ABSTRACT:
SUBMITTER: Ferrari A
PROVIDER: S-EPMC4947184 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Nature communications 20160713
HER2-positive breast cancer has long proven to be a clinically distinct class of breast cancers for which several targeted therapies are now available. However, resistance to the treatment associated with specific gene expressions or mutations has been observed, revealing the underlying diversity of these cancers. Therefore, understanding the full extent of the HER2-positive disease heterogeneity still remains challenging. Here we carry out an in-depth genomic characterization of 64 HER2-positiv ...[more]