Ontology highlight
ABSTRACT:
SUBMITTER: Warner KA
PROVIDER: S-EPMC4947417 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Warner Kristy A KA Nör Felipe F Acasigua Gerson A GA Martins Manoela D MD Zhang Zhaocheng Z McLean Scott A SA Spector Matthew E ME Chepeha Douglas B DB Helman Joseph J Wick Michael J MJ Moskaluk Christopher A CA Castilho Rogerio M RM Pearson Alexander T AT Wang Shaomeng S Nör Jacques E JE
Clinical cancer research : an official journal of the American Association for Cancer Research 20160302 14
<h4>Purpose</h4>There are no effective treatment options for patients with advanced adenoid cystic carcinoma (ACC). Here, we evaluated the effect of a new small molecule inhibitor of the MDM2-p53 interaction (MI-773) in preclinical models of ACC.<h4>Experimental design</h4>To evaluate the anti-tumor effect of MI-773, we administered it to mice harboring three different patient-derived xenograft (PDX) models of ACC expressing functional p53. The effect of MI-773 on MDM2, p53, phospho-p53, and p21 ...[more]