Ontology highlight
ABSTRACT:
SUBMITTER: Zhao B
PROVIDER: S-EPMC4947919 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Zhao Baoming B Wang Jing J Liu Lu L Li Xing X Liu Shuangxi S Xia Qian Q Shi Jing J
Scientific reports 20160718
Annexin A1 (ANXA1) is a protein known to have multiple roles in the regulation of inflammatory responses. In this study, we find that after oxygen glucose deprivation/reoxygenation (ODG/R) injury, activated PKC phosphorylated ANXA1 at the serine 27 residue (p27S-ANXA1), and promoted the translocation of p27S-ANXA1 to the nucleus of BV-2 microglial cells. This in turn induced BV-2 microglial cells to produce large amounts of pro-inflammatory cytokines. The phenomenon could be mimicked by either t ...[more]