Ontology highlight
ABSTRACT:
SUBMITTER: Purushottamachar P
PROVIDER: S-EPMC4948004 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Purushottamachar Puranik P Kwegyir-Afful Andrew K AK Martin Marlena S MS Ramamurthy Vidya P VP Ramalingam Senthilmurugan S Njar Vincent C O VC
ACS medicinal chemistry letters 20160523 7
Degradation of all forms of androgen receptors (ARs) is emerging as an advantageous therapeutic paradigm for the effective treatment of prostate cancer. In continuation of our program to identify and develop improved efficacious novel small-molecule agents designed to disrupt AR signaling through enhanced AR degradation, we have designed, synthesized, and evaluated novel C-3 modified analogues of our phase 3 clinical agent, galeterone (5). Concerns of potential in vivo stability of our recently ...[more]