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ABSTRACT:
SUBMITTER: Hampannavar GA
PROVIDER: S-EPMC4948005 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Hampannavar Girish A GA Karpoormath Rajshekhar R Palkar Mahesh B MB Shaikh Mahamadhanif S MS Chandrasekaran Balakumar B
ACS medicinal chemistry letters 20160513 7
Series of styryl hydrazine thiazole hybrids inspired from dehydrozingerone (DZG) scaffold were designed and synthesized by molecular hybridization approach. In vitro antimycobacterial activity of synthesized compounds was evaluated against Mycobacterium tuberculosis H37Rv strain. Among the series, compound 6o exhibited significant activity (MIC = 1.5 μM; IC50 = 0.48 μM) along with bactericidal (MBC = 12 μM) and intracellular antimycobacterial activities (IC50 = <0.098 μM). Furthermore, 6o displa ...[more]