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The genomic basis of parasitism in the Strongyloides clade of nematodes.

ABSTRACT: Soil-transmitted nematodes, including the Strongyloides genus, cause one of the most prevalent neglected tropical diseases. Here we compare the genomes of four Strongyloides species, including the human pathogen Strongyloides stercoralis, and their close relatives that are facultatively parasitic (Parastrongyloides trichosuri) and free-living (Rhabditophanes sp. KR3021). A significant paralogous expansion of key gene families--families encoding astacin-like and SCP/TAPS proteins--is associated with the evolution of parasitism in this clade. Exploiting the unique Strongyloides life cycle, we compare the transcriptomes of the parasitic and free-living stages and find that these same gene families are upregulated in the parasitic stages, underscoring their role in nematode parasitism.

SUBMITTER: Hunt VL 

PROVIDER: S-EPMC4948059 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature

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The genomic basis of parasitism in the Strongyloides clade of nematodes.

Hunt Vicky L VL   Tsai Isheng J IJ   Coghlan Avril A   Reid Adam J AJ   Holroyd Nancy N   Foth Bernardo J BJ   Tracey Alan A   Cotton James A JA   Stanley Eleanor J EJ   Beasley Helen H   Bennett Hayley M HM   Brooks Karen K   Harsha Bhavana B   Kajitani Rei R   Kulkarni Arpita A   Harbecke Dorothee D   Nagayasu Eiji E   Nichol Sarah S   Ogura Yoshitoshi Y   Quail Michael A MA   Randle Nadine N   Xia Dong D   Brattig Norbert W NW   Soblik Hanns H   Ribeiro Diogo M DM   Sanchez-Flores Alejandro A   Hayashi Tetsuya T   Itoh Takehiko T   Denver Dee R DR   Grant Warwick W   Stoltzfus Jonathan D JD   Lok James B JB   Murayama Haruhiko H   Wastling Jonathan J   Streit Adrian A   Kikuchi Taisei T   Viney Mark M   Berriman Matthew M  

Nature genetics 20160201 3

Soil-transmitted nematodes, including the Strongyloides genus, cause one of the most prevalent neglected tropical diseases. Here we compare the genomes of four Strongyloides species, including the human pathogen Strongyloides stercoralis, and their close relatives that are facultatively parasitic (Parastrongyloides trichosuri) and free-living (Rhabditophanes sp. KR3021). A significant paralogous expansion of key gene families--families encoding astacin-like and SCP/TAPS proteins--is associated w  ...[more]

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