Ontology highlight
ABSTRACT:
SUBMITTER: Penner MR
PROVIDER: S-EPMC4949137 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Penner M R MR Parrish R R RR Hoang L T LT Roth T L TL Lubin F D FD Barnes C A CA
Hippocampus 20160404 8
Aged animals show functional alterations in hippocampal neurons that lead to deficits in synaptic plasticity and changes in cognitive function. Transcription of immediate-early genes (IEGs), including Egr1, is necessary for processes such as long-term potentiation and memory consolidation. Here, we show an age-related reduction in the transcription of Egr1 in the dentate gyrus following spatial behavior, whereas in the area CA1, Egr1 is reduced at rest, but its transcription can be effectively d ...[more]