Ontology highlight
ABSTRACT:
SUBMITTER: Weil MT
PROVIDER: S-EPMC4949381 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Weil Marie-Theres MT Möbius Wiebke W Winkler Anne A Ruhwedel Torben T Wrzos Claudia C Romanelli Elisa E Bennett Jeffrey L JL Enz Lukas L Goebels Norbert N Nave Klaus-Armin KA Kerschensteiner Martin M Schaeren-Wiemers Nicole N Stadelmann Christine C Simons Mikael M
Cell reports 20160623 2
Breakdown of myelin sheaths is a pathological hallmark of several autoimmune diseases of the nervous system. We employed autoantibody-mediated animal models of demyelinating diseases, including a rat model of neuromyelitis optica (NMO), to target myelin and found that myelin lamellae are broken down into vesicular structures at the innermost region of the myelin sheath. We demonstrated that myelin basic proteins (MBP), which form a polymer in between the myelin membrane layers, are targeted in t ...[more]