Dataset Information

Interpregnancy interval and perinatal outcomes across Latin America from 1990 to 2009: a large multi-country study.

ABSTRACT:

Objective

To determine the relationship of interpregnancy interval with maternal and offspring outcomes.

Design

Retrospective study with data from the Perinatal Information System database of the Latin American Centre for Perinatology and Human Development, Uruguay.

Setting

Latin America, 1990-2009.

Population

A cohort of 894 476 women delivering singleton infants.

Methods

During 1990-2009 the Perinatal Information System database of the Latin American Centre for Perinatology identified 894 476 women with defined interpregnancy intervals: i.e. the time elapsed between the date of the previous delivery and the first day of the last normal menstrual period for the index pregnancy. Using the interval 12-23 months as the reference category, multiple logistic regression estimated adjusted odds ratios (aORs) with 95% confidence intervals (95% CIs) of the association between various interval lengths and maternal and offspring outcomes.

Main outcome measures

Maternal death, pre-eclampsia, eclampsia, puerperal infection, fetal death, neonatal death, preterm birth, and low birthweight.

Results

In the reference interval there was 0.05% maternal death, 1.00% postpartum haemorrhage, 2.80% pre-eclampsia, 0.15% eclampsia, 0.28% puerperal infection, 3.45% fetal death, 0.68% neonatal death, 12.33% preterm birth, and 9.73% low birthweight. Longer intervals had increased odds of pre-eclampsia (>72 months), fetal death (>108-119 months), and low birthweight (96-107 months). Short intervals of <12 months had increased odds of pre-eclampsia (aOR 0.80; 95% CI 0.76-0.85), neonatal death (aOR 1.18; 95% CI 1.08-1.28), and preterm birth (aOR 1.16; 95% CI 1.11-1.21). Statistically, the interval had no relationship with maternal death, eclampsia, and puerperal infection.

Conclusions

A short interpregnancy interval of <12 months is associated with pre-eclampsia, neonatal mortality, and preterm birth, but not with other maternal or offspring outcomes. Longer intervals of >72 months are associated with pre-eclampsia, fetal death, and low birthweight, but not with other maternal or offspring outcomes.

Tweetable abstract

A short interpregnancy interval of <12 months is associated with neonatal mortality and preterm birth.

SUBMITTER: Mignini LE

PROVIDER: S-EPMC4949506 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature

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Publications

Interpregnancy interval and perinatal outcomes across Latin America from 1990 to 2009: a large multi-country study.

Mignini L E LE Carroli G G Betran A P AP Fescina R R Cuesta C C Campodonico L L De Mucio B B Khan K S KS

BJOG : an international journal of obstetrics and gynaecology 20150924 5

<h4>Objective</h4>To determine the relationship of interpregnancy interval with maternal and offspring outcomes.<h4>Design</h4>Retrospective study with data from the Perinatal Information System database of the Latin American Centre for Perinatology and Human Development, Uruguay.<h4>Setting</h4>Latin America, 1990-2009.<h4>Population</h4>A cohort of 894 476 women delivering singleton infants.<h4>Methods</h4>During 1990-2009 the Perinatal Information System database of the Latin American Centre ...[more]

PMID: 26399217

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Dataset Information

Interpregnancy interval and perinatal outcomes across Latin America from 1990 to 2009: a large multi-country study.

Objective

Design

Setting

Population

Methods

Main outcome measures

Results

Conclusions

Tweetable abstract

Publications

Interpregnancy interval and perinatal outcomes across Latin America from 1990 to 2009: a large multi-country study.

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