Dataset Information

Maternal smoking in pregnancy association with childhood adiposity and blood pressure.

ABSTRACT:

Background

Maternal smoking during pregnancy has been associated with increased risk of childhood overweight/obesity defined by body mass index (BMI). We examined its association with a range of adiposity measures and cardiovascular indicators in children aged 3-10 years.

Methods

We used data from a cross-sectional study of schoolchildren across mainland Portuguese districts (2009-2010). We applied quantile regressions to examine maternal smoking associations with adiposity (n?=?17?286), blood pressure (BP) and resting pulse rate (RPR) (n???2500) measures across the age range, adjusting for prenatal and early life factors.

Results

Maternal smoking during pregnancy was associated with increases in offspring adiposity levels. The difference in median BMI between children of smokers and non-smokers was 0.39?kg?m(-2) (95% confidence interval: 0.25, 0.53) in boys and 0.46?kg?m(-2) (0.31, 0.62) in girls; 0.55?cm (0.24, 0.87) and 0.82?cm (0.45, 1.19), respectively, in median waist circumference; and 0.94?mm (0.49, 1.40) and 1.47?mm (0.87, 2.07) in median sum of (triceps, subscapular, suprailiac) skin-folds. The associations appeared to be stronger with increasing age. The differences in the 90th centile tended to be greater than those in median. There was no consistent association of maternal smoking with BP and RPR.

Conclusions

Children whose mother smoked during pregnancy had higher adiposity levels than children of non-smokers, across several measures, particularly among older children. Although there was no consistent association with cardiovascular indicators, maternal smoking association with childhood obesity may have implications for cardiovascular risk factors over the life course.

SUBMITTER: Li L

PROVIDER: S-EPMC4949567 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature

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Publications

Maternal smoking in pregnancy association with childhood adiposity and blood pressure.

Li L L Peters H H Gama A A Carvalhal M I M MI Nogueira H G M HG Rosado-Marques V V Padez C C

Pediatric obesity 20150714 3

<h4>Background</h4>Maternal smoking during pregnancy has been associated with increased risk of childhood overweight/obesity defined by body mass index (BMI). We examined its association with a range of adiposity measures and cardiovascular indicators in children aged 3-10 years.<h4>Methods</h4>We used data from a cross-sectional study of schoolchildren across mainland Portuguese districts (2009-2010). We applied quantile regressions to examine maternal smoking associations with adiposity (n = 1 ...[more]

PMID: 26178147

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Project description:BackgroundMaternal polyunsaturated fatty acid (PUFA) concentrations during pregnancy may have persistent effects on growth and adiposity in the offspring. A suboptimal maternal diet during pregnancy might lead to fetal cardiometabolic adaptations with persistent consequences in the offspring.ObjectiveWe examined the associations of maternal PUFA concentrations during pregnancy with childhood general and abdominal fat-distribution measures.DesignIn a population-based, prospective cohort study of 4830 mothers and their children, we measured maternal second-trimester plasma n-3 (ω-3) and n-6 (ω-6) PUFA concentrations. At the median age of 6.0 y (95% range: 5.6, 7.9 y), we measured childhood body mass index (BMI), the fat mass percentage, and the android:gynoid fat ratio with the use of dual-energy X-ray absorptiometry and measured the preperitoneal abdominal fat area with the use of ultrasound. Analyses were adjusted for maternal and childhood sociodemographic- and lifestyle-related characteristics.ResultsWe observed that higher maternal total n-3 PUFA concentrations, and specifically those of eicosapentaenoic acid, docosapentaenoic acid, and docosahexaenoic acid, were associated with a lower childhood total-body fat percentage and a lower android:gynoid fat mass ratio (P< 0.05) but not with childhood BMI and the abdominal preperitoneal fat mass area. Higher maternal total n-6 PUFA concentrations, and specifically those of dihomo-γ-linolenic acid, were associated with a higher childhood total-body fat percentage, android:gynoid fat mass ratio, and abdominal preperitoneal fat mass area (P< 0.05) but not with childhood BMI. In line with these findings, a higher maternal n-6:n-3 PUFA ratio was associated with higher childhood total-body and abdominal fat mass.ConclusionsLower maternal n-3 PUFA concentrations and higher n-6 PUFA concentrations during pregnancy are associated with higher body fat and abdominal fat in childhood. Additional studies are needed to replicate these observations and to explore the causality, the underlying pathways, and the long-term cardiometabolic consequences.

Dataset Information

Maternal smoking in pregnancy association with childhood adiposity and blood pressure.

Background

Methods

Results

Conclusions

Publications

Maternal smoking in pregnancy association with childhood adiposity and blood pressure.

Similar Datasets

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