Ontology highlight
ABSTRACT:
SUBMITTER: Gacek-Matthews A
PROVIDER: S-EPMC4949671 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Gacek-Matthews Agnieszka A Noble Luke M LM Gruber Clemens C Berger Harald H Sulyok Michael M Marcos Ana T AT Strauss Joseph J Andrianopoulos Alex A
Molecular microbiology 20150411 4
Aspergillus nidulans kdmA encodes a member of the KDM4 family of jumonji histone demethylase proteins, highly similar to metazoan orthologues both within functional domains and in domain architecture. This family of proteins exhibits demethylase activity towards lysines 9 and 36 of histone H3 and plays a prominent role in gene expression and chromosome structure in many species. Mass spectrometry mapping of A. nidulans histones revealed that around 3% of bulk histone H3 carried trimethylated H3K ...[more]