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MYEOV gene overexpression in primary plasma cell leukemia with t(11;14)(q13;q32).

ABSTRACT: Primary plasma cell leukemia (pPCL) is an uncommon form of plasma cell dyscrasia, and the most aggressive of the human monoclonal gammopathies. The t(11;14)(q13;q32) rearrangement is the most common alteration in pPCL, promoting cyclin D1 (CCND1) gene overexpression caused by its juxtaposition with the immunoglobulin heavy locus chromosome region. The myeloma overexpressed (MYEOV) gene maps very close to the CCND1 gene on chromosome 11, but its overexpression is rarely observed in multiple myeloma. The present study describes a case of pPCL with t(11;14) characterized by a breakpoint on der(11), unlike the one usually observed. Droplet digital polymerase chain reaction analysis revealed overexpression of CCND1 and MYEOV. To the best of our knowledge, MYEOV gene overexpression has never been previously described in pPCL.

SUBMITTER: Coccaro N 

PROVIDER: S-EPMC4950221 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature

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Primary plasma cell leukemia (pPCL) is an uncommon form of plasma cell dyscrasia, and the most aggressive of the human monoclonal gammopathies. The t(11;14)(q13;q32) rearrangement is the most common alteration in pPCL, promoting <i>cyclin D1</i> (<i>CCND1</i>) gene overexpression caused by its juxtaposition with the <i>immunoglobulin heavy locus</i> chromosome region. The <i>myeloma overexpressed</i> (<i>MYEOV</i>) gene maps very close to the <i>CCND1</i> gene on chromosome 11, but its overexpre  ...[more]

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