Dataset Information

Changes in Cardiovascular Health Status and the Risk of New-Onset Hypertension in Kailuan Cohort Study.

ABSTRACT: American Heart Association cardiovascular health metrics are intimately related to cardiovascular diseases. Acting as a key independent risk factor for high morbidity and mortality of cardiovascular diseases, hypertension and its relationship between health status get urgent attention. While the influence of individual health status changes and the future risk of new-onset hypertension is rarely understood, the present study applied this construct to assess the changes of cardiovascular health status and the morbidity of hypertension in Kailuan cohort study in north China. The Cardiovascular Health Score (CHS) was evaluated by the follow-ups of 2006-2007, 2008-2009, 2010-2011 and 2012-2013. The study population (n = 19381) was divided into 5 groups based on the changes in their CHS score between the first two follow-ups (?CHS) of 2006-2007 and 2008-2009 (?-2, -1, 0, 1, ?2). The morbidity of hypertension was collected during 2010-2011 and 2012-2013 follow-ups. Data analysis showed that during a median follow-up of 3.79±0.96 years, morbidity of hypertension had a graded relationship with ?CHS. As ?CHS scored from low to high, the standardized morbidity of hypertension for all participants were 81.40, 75.47, 68.37, 71.43 and 83.13 per 1000 person-year, respectively. An increased ?CHS score of 1 was associated with a 10% decrease in the future risk of new-onset hypertension(HR: 0.90, 95% CI: 0.88-0.92). In conclusion, there was a strong inverse relationship between the incidence of new-onset hypertension and elevation of cardiovascular health metrics. Population-wide prevention, especially the promotion of lifestyle improvements, is critical to reducing the morbidity of new-onset hypertension.

SUBMITTER: Gao F

PROVIDER: S-EPMC4951012 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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Changes in Cardiovascular Health Status and the Risk of New-Onset Hypertension in Kailuan Cohort Study.

Gao Fei F Liu Xiaoxue X Wang Xizhu X Chen Shouhua S Shi Jihong J Zhang Ying Y Wu Shouling S Cai Jun J

PloS one 20160719 7

American Heart Association cardiovascular health metrics are intimately related to cardiovascular diseases. Acting as a key independent risk factor for high morbidity and mortality of cardiovascular diseases, hypertension and its relationship between health status get urgent attention. While the influence of individual health status changes and the future risk of new-onset hypertension is rarely understood, the present study applied this construct to assess the changes of cardiovascular health s ...[more]

PMID: 27434049

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Project description:Suboptimal health status (SHS) is recognized as a subclinical, reversible stage of chronic disease. Association has been confirmed between SHS and cardiovascular risk factors, indicating that SHS may contribute to the development of cardiovascular disease. This study explored integrated risk assessment of cardiovascular disease by combining SHS questionnaire-25 (SHSQ-25) and indicators of endothelial dysfunction.A community-based cross-sectional study was conducted in a sample of 459 residents of Samara, Russia, who had no history of clinical diagnosed disease and did not receive any treatment in the last 2 weeks. The SHS score was derived from the data collected in the SHSQ-25. Blood pressure, body mass index, and glucose and lipid levels (total cholesterol, low density lipoprotein, cholesterol and triglycerides) were measured by physical examination and laboratory performance. The relationship between SHS and endothelial dysfunction was examined using Pearson's correlation linear regression analysis. Cluster analysis was performed to identify systemic patterns arising from exposure to a variety of risk factors.Significant correlations were observed between index of endothelial function and the overall performance of SHS (r = -0.31, p < 0.05), and individual scales of the questionnaire SHSQ-25: fatigue (r = -0.36, p < 0.05), mental (r = -0.29, p < 0.05), and the cardiovascular system (r = -0.36). Based on cluster analysis, all subjects were grouped into five clusters: (1) optimal health status, (2) SHS at low risk of disease states, (3) SHS with a high risk of non-cardiac pathologies profile, (4) SHS of low risk of cardiovascular disease, and (5) SHS with high risk of cardiovascular disease.SHS is associated with endothelial dysfunction. Integration of suboptimal health status and endothelial dysfunction provides a novel tool to allow people to get a more holistic picture of both subjective and objective health measures, and also can be applied to routine screening for risks of cardiovascular diseases.

Project description:ObjectiveThe purpose of our study was to investigate the association of obesity status change with hypertension onset based on a community-based longitudinal cohort study in North China.MethodsThis longitudinal study included 3,581 individuals free of hypertension at baseline in the first survey (2011-2012). All participants were followed up (2018-2019). According to the criteria, a total of 2,618 individuals were collected for analysis. We used adjusted Cox regression models and Kaplan-Meier survival analysis to estimate the association between obesity status change and hypertension onset. Additionally, we applied the forest plot to visualize the subgroup analysis including age, gender, and the differences in some variables between baseline and follow-up. Finally, we conducted a sensitivity analysis to examine the stability of our results.ResultsOver nearly 7 years of follow-up, a total of 811 (31%) developed hypertension. The new hypertension incidence was mostly observed in those who were obese all the time (P for trend < 0.01). In the fully adjusted Cox regression model, being obese all the time increased the risk of hypertension by 30.10% [HR 4.01 (95% CI 2.20-7.32)]. The Kaplan-Meier survival analysis revealed the change in obesity status as an important feature to predict the occurrence of hypertension. Sensitivity analysis shows a consistent trend between the change in obesity status and hypertension onset in all populations. Subgroup analysis showed that age above 60 years was an important risk factor for hypertension onset, that men were more likely than women to develop hypertension, and that weight control was beneficial in avoiding future hypertension in women. There were statistically significant differences in ΔBMI, ΔSBP, ΔDBP, and ΔbaPWV between the four groups, and all variables, except baPWV changes, increased the risk of future hypertension.ConclusionOur study shows that obese status was notably associated with a significant risk of hypertension onset among the Chinese community-based cohort.

Dataset Information

Changes in Cardiovascular Health Status and the Risk of New-Onset Hypertension in Kailuan Cohort Study.

Publications

Changes in Cardiovascular Health Status and the Risk of New-Onset Hypertension in Kailuan Cohort Study.

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