Impact of early cART in the gut during acute HIV infection.

ABSTRACT: Early after HIV infection there is substantial depletion of CD4⁺ T cells in the gastrointestinal (GI) tract lamina propria (LP), with associated epithelial barrier damage, leading to microbial translocation and systemic inflammation and immune activation. In this study, we analyzed these early events in the GI tract in a cohort of Thai acute HIV-infected patients and determined the effect of early combination antiretroviral treatment (cART). HIV-uninfected and chronically and acutely HIV-infected patients at different Fiebig stages (I-V) underwent colonic biopsies and then received cART. Immunohistochemistry and quantitative image analysis were performed on cross-sectional and longitudinal colon biopsy specimens (day 0 to week 96) to measure GI tract damage (infiltration of poly

SUBMITTER: Deleage C 

PROVIDER: S-EPMC4951101 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature