Ontology highlight
ABSTRACT:
SUBMITTER: Kucejova B
PROVIDER: S-EPMC4951107 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Kucejova Blanka B Duarte Joao J Satapati Santhosh S Fu Xiaorong X Ilkayeva Olga O Newgard Christopher B CB Brugarolas James J Burgess Shawn C SC
Cell reports 20160623 2
Dysregulated mitochondrial metabolism during hepatic insulin resistance may contribute to pathophysiologies ranging from elevated glucose production to hepatocellular oxidative stress and inflammation. Given that obesity impairs insulin action but paradoxically activates mTORC1, we tested whether insulin action and mammalian target of rapamycin complex 1 (mTORC1) contribute to altered in vivo hepatic mitochondrial metabolism. Loss of hepatic insulin action for 2 weeks caused increased gluconeoge ...[more]