Unknown

Dataset Information

0

Intestinal Microbiota Promotes Psoriasis-Like Skin Inflammation by Enhancing Th17 Response.


ABSTRACT: Psoriasis is a chronic inflammatory skin disease in which Th17 cells play a crucial role. Since indigenous gut microbiota influences the development and reactivity of immune cells, we analyzed the link among microbiota, T cells and the formation of psoriatic lesions in the imiquimod-induced murine model of psoriasis. To explore the role of microbiota, we induced skin inflammation in germ-free (GF), broad-spectrum antibiotic (ATB)-treated or conventional (CV) BALB/c and C57BL/6 mice. We found that both mice reared in GF conditions for several generations and CV mice treated with ATB were more resistant to imiquimod-induced skin inflammation than CV mice. The ATB treatment dramatically changed the diversity of gut bacteria, which remained stable after subsequent imiquimod application; ATB treatment resulted in a substantial increase in the order Lactobacillales and a significant decrease in Coriobacteriales and Clostridiales. Moreover, as compared to CV mice, imiquimod induced a lower degree of local and systemic Th17 activation in both GF and ATB-treated mice. These findings suggest that gut microbiota control imiquimod-induced skin inflammation by altering the T cell response.

SUBMITTER: Zakostelska Z 

PROVIDER: S-EPMC4951142 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

altmetric image

Publications


Psoriasis is a chronic inflammatory skin disease in which Th17 cells play a crucial role. Since indigenous gut microbiota influences the development and reactivity of immune cells, we analyzed the link among microbiota, T cells and the formation of psoriatic lesions in the imiquimod-induced murine model of psoriasis. To explore the role of microbiota, we induced skin inflammation in germ-free (GF), broad-spectrum antibiotic (ATB)-treated or conventional (CV) BALB/c and C57BL/6 mice. We found tha  ...[more]

Similar Datasets

| S-EPMC5983326 | biostudies-literature
| S-EPMC8553570 | biostudies-literature
| S-EPMC5555377 | biostudies-literature
| S-EPMC3601830 | biostudies-literature
| S-EPMC2200300 | biostudies-literature
| S-EPMC4235643 | biostudies-literature
| S-EPMC8927994 | biostudies-literature
| S-EPMC8958354 | biostudies-literature
| S-EPMC3221838 | biostudies-literature
| S-EPMC3546056 | biostudies-other