Ontology highlight
ABSTRACT:
SUBMITTER: Grammatikos G
PROVIDER: S-EPMC4951274 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Grammatikos Georgios G Schoell Niklas N Ferreirós Nerea N Bon Dimitra D Herrmann Eva E Farnik Harald H Köberle Verena V Piiper Albrecht A Zeuzem Stefan S Kronenberger Bernd B Waidmann Oliver O Pfeilschifter Josef J
Oncotarget 20160401 14
We have recently shown that major alterations of serum sphingolipid metabolites in chronic liver disease associate significantly with the stage of liver fibrosis in corresponding patients. In the current study we assessed via mass spectrometry serum concentrations of sphingolipid metabolites in a series of 122 patients with hepatocellular carcinoma (HCC) compared to an age- and sex-matched series of 127 patients with cirrhosis. We observed a highly significant upregulation of long and very long ...[more]