Ontology highlight
ABSTRACT:
SUBMITTER: Carroll BL
PROVIDER: S-EPMC4951279 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Carroll Brittany L BL Pulkoski-Gross Michael J MJ Hannun Yusuf A YA Obeid Lina M LM
Oncotarget 20160401 14
The recently discovered CHK1-Suppressed (CS) pathway is activated by inhibition or loss of the checkpoint kinase CHK1, promoting an apoptotic response to DNA damage mediated by caspase-2 in p53-deficient cells. Although functions of the CS-pathway have been investigated biochemically, it remains unclear whether and how CHK1 inhibition can be regulated endogenously and whether this constitutes a key component of the DNA damage response (DDR). Here, we present data that define the first endogenous ...[more]