Ontology highlight
ABSTRACT:
SUBMITTER: Yano S
PROVIDER: S-EPMC4951309 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Yano Shuya S Takehara Kiyoto K Kishimoto Hiroyuki H Urata Yasuo Y Kagawa Shunsuke S Bouvet Michael M Fujiwara Toshiyoshi T Hoffman Robert M RM
Oncotarget 20160401 14
Malignant melanoma requires precise resection in order to avoid metastatic recurrence. We report here that the telomerase-dependent, green fluorescent protein (GFP)-containing adenovirus OBP-401 could label malignant melanoma with GFP in situ in orthotopic mouse models. OBP-401-based fluorescence-guided surgery (FGS) resulted in the complete resection of malignant melanoma in the orthotopic models, where conventional bright-light surgery (BLS) could not. High-dose administration of OBP-401 enabl ...[more]