Ontology highlight
ABSTRACT:
SUBMITTER: Wu H
PROVIDER: S-EPMC4951653 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Wu Hongyu H Bogdanov Mikhail M Zhang Yujin Y Sun Kaiqi K Zhao Shushan S Song Anren A Luo Renna R Parchim Nicholas F NF Liu Hong H Huang Aji A Adebiyi Morayo G MG Jin Jianping J Alexander Danny C DC Milburn Michael V MV Idowu Modupe M Juneja Harinder S HS Kellems Rodney E RE Dowhan William W Xia Yang Y
Scientific reports 20160720
Although Lands' cycle was discovered in 1958, its function and cellular regulation in membrane homeostasis under physiological and pathological conditions remain largely unknown. Nonbiased high throughput metabolomic profiling revealed that Lands' cycle was impaired leading to significantly elevated erythrocyte membrane lysophosphatidylcholine (LysoPC) content and circulating and erythrocyte arachidonic acid (AA) in mice with sickle cell disease (SCD), a prevalent hemolytic genetic disorder. Cor ...[more]