Ontology highlight
ABSTRACT:
SUBMITTER: Harris FR
PROVIDER: S-EPMC4951715 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Harris Faye R FR Kovtun Irina V IV Smadbeck James J Multinu Francesco F Jatoi Aminah A Kosari Farhad F Kalli Kimberly R KR Murphy Stephen J SJ Halling Geoffrey C GC Johnson Sarah H SH Liu Minetta C MC Mariani Andrea A Vasmatzis George G
Scientific reports 20160720
Recently, the use of a liquid biopsy has shown promise in monitoring tumor burden. While point mutations have been extensively studied, chromosomal rearrangements have demonstrated greater tumor specificity. Such rearrangements can be identified in the tumor and subsequently detected in the plasma of patients using quantitative PCR (qPCR). In this study we used a whole-genome mate-pair protocol to characterize a landscape of genomic rearrangements in the primary tumors of ten ovarian cancer pati ...[more]