Ontology highlight
ABSTRACT:
SUBMITTER: Wang SB
PROVIDER: S-EPMC4951730 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Wang Shi-Bo SB Wen Yang-Jun YJ Ren Wen-Long WL Ni Yuan-Li YL Zhang Jin J Feng Jian-Ying JY Zhang Yuan-Ming YM
Scientific reports 20160720
Composite interval mapping (CIM) is the most widely-used method in linkage analysis. Its main feature is the ability to control genomic background effects via inclusion of co-factors in its genetic model. However, the result often depends on how the co-factors are selected, especially for small-effect and linked quantitative trait loci (QTL). To address this issue, here we proposed a new method under the framework of genome-wide association studies (GWAS). First, a single-locus random-SNP-effect ...[more]