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PIMADb: A Database of Protein-Protein Interactions in Huge Macromolecular Assemblies.

ABSTRACT: Protein-protein interactions play a very important role in the process of cellular functionality. Intricate details about the interactions between the proteins in a macromolecular assembly are important to understand the function and significance of protein complexes. We are reporting about a database of protein-protein interactions in huge macromolecular assemblies (PIMADb) that records the intrinsic details of 189,532 interchain interactions in 40,049 complexes from the Protein Data Bank. These details include the results of the quantification and analysis of all the interactions in the complex. The availability of interprotomer interaction networks can enable the design of point mutation experiments. PIMADb can be accessed from the URL: http://caps.ncbs.res.in/pimadb.

SUBMITTER: Mathew OK

PROVIDER: S-EPMC4954588 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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PIMADb: A Database of Protein-Protein Interactions in Huge Macromolecular Assemblies.

Mathew Oommen K OK Sowdhamini Ramanathan R

Bioinformatics and biology insights 20160719

Protein-protein interactions play a very important role in the process of cellular functionality. Intricate details about the interactions between the proteins in a macromolecular assembly are important to understand the function and significance of protein complexes. We are reporting about a database of protein-protein interactions in huge macromolecular assemblies (PIMADb) that records the intrinsic details of 189,532 interchain interactions in 40,049 complexes from the Protein Data Bank. Thes ...[more]

PMID: 27478368

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