Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.
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ABSTRACT:
SUBMITTER: Selman C
PROVIDER: S-EPMC4954603 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Publications
Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.
Selman Colin C Tullet Jennifer M A JM Wieser Daniela D Irvine Elaine E Lingard Steven J SJ Choudhury Agharul I AI Claret Marc M Al-Qassab Hind H Carmignac Danielle D Ramadani Faruk F Woods Angela A Robinson Iain C A IC Schuster Eugene E Batterham Rachel L RL Kozma Sara C SC Thomas George G Carling David D Okkenhaug Klaus K Thornton Janet M JM Partridge Linda L Gems David D Withers Dominic J DJ
Science (New York, N.Y.) 20091001 5949
Caloric restriction (CR) protects against aging and disease, but the mechanisms by which this affects mammalian life span are unclear. We show in mice that deletion of ribosomal S6 protein kinase 1 (S6K1), a component of the nutrient-responsive mTOR (mammalian target of rapamycin) signaling pathway, led to increased life span and resistance to age-related pathologies, such as bone, immune, and motor dysfunction and loss of insulin sensitivity. Deletion of S6K1 induced gene expression patterns si ...[more]
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