Validation of a Radiography-Based Quantification Designed to Longitudinally Monitor Soft Tissue Calcification in Skeletal Muscle.
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ABSTRACT:
SUBMITTER: Moore SN
PROVIDER: S-EPMC4954695 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Publications
Validation of a Radiography-Based Quantification Designed to Longitudinally Monitor Soft Tissue Calcification in Skeletal Muscle.
Moore Stephanie N SN Hawley Gregory D GD Smith Emily N EN Mignemi Nicholas A NA Ihejirika Rivka C RC Yuasa Masato M Cates Justin M M JM Liu Xulei X Schoenecker Jonathan G JG
PloS one 20160720 7
<h4>Introduction</h4>Soft tissue calcification, including both dystrophic calcification and heterotopic ossification, may occur following injury. These lesions have variable fates as they are either resorbed or persist. Persistent soft tissue calcification may result in chronic inflammation and/or loss of function of that soft tissue. The molecular mechanisms that result in the development and maturation of calcifications are uncertain. As a result, directed therapies that prevent or resorb soft ...[more]
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