Ontology highlight
ABSTRACT:
SUBMITTER: Meng XY
PROVIDER: S-EPMC4954981 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Meng Xuan-Yu XY Liu Shengtang S Cui Meng M Zhou Ruhong R Logothetis Diomedes E DE
Scientific reports 20160721
Inwardly rectifying K(+) (Kir) channels, serving as natural molecular nanomachines, transport potassium ions across the plasma membrane of the cell. Along the ion permeation pathway, three relatively narrow regions (the selectivity filter (SF), the inner helix bundle crossing (HBC), and the cytosolic G loop) may serve as gates to control ion permeation. Our previous molecular dynamics simulations based on the crystal structure of a Kir3.1 chimera revealed the possible gating mechanism of the G l ...[more]