Virtual screening and experimental validation of novel histone deacetylase inhibitors.

ABSTRACT:

Background

Histone deacetylases (HDACs) are promising therapeutic targets for the treatment of cancer, diabetes and other human diseases. HDAC inhibitors, as a new class of potential therapeutic agents, have attracted a great deal of interest for both research and clinical applications. Increasing efforts have been focused on the discovery of HDAC inhibitors and some HDAC inhibitors have been approved for use in cancer therapy. However, most HDAC inhibitors, including the clinically approved agents, do not selectively inhibit the deacetylase activity of class I and II HDAC isforms, and many suffer from metabolic instability. This study aims to identify new HDAC inhibitors by using a high-throughput virtual screening approach.

Methods

An integration of in silico virtual scree

SUBMITTER: Huang YX 

PROVIDER: S-EPMC4955146 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature