Ontology highlight
ABSTRACT:
SUBMITTER: Parmeggiani F
PROVIDER: S-EPMC4955227 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Parmeggiani Fabio F Lovelock Sarah L SL Weise Nicholas J NJ Ahmed Syed T ST Turner Nicholas J NJ
Angewandte Chemie (Weinheim an der Bergstrasse, Germany) 20150226 15
The synthesis of substituted d-phenylalanines in high yield and excellent optical purity, starting from inexpensive cinnamic acids, has been achieved with a novel one-pot approach by coupling phenylalanine ammonia lyase (PAL) amination with a chemoenzymatic deracemization (based on stereoselective oxidation and nonselective reduction). A simple high-throughput solid-phase screening method has also been developed to identify PALs with higher rates of formation of non-natural d-phenylalanines. The ...[more]