Pretreatment blood-brain barrier disruption and post-endovascular intracranial hemorrhage.

ABSTRACT:

Objective

This study sought to confirm the relationship between the degree of blood-brain barrier (BBB) damage and the severity of intracranial hemorrhage (ICH) in a population of patients who received endovascular therapy.

Methods

The degree of BBB disruption on pretreatment MRI scans was analyzed, blinded to follow-up data, in the DEFUSE 2 cohort in which patients had endovascular therapy within 12 hours of stroke onset. BBB disruption was compared with ICH grade previously established by the DEFUSE 2 core lab. A prespecified threshold for predicting parenchymal hematoma (PH) was tested.

Results

Of the 108 patients in the DEFUSE 2 trial, 100 had adequate imaging and outcome data and were included in this study; 24 developed PH. Increasing amounts of BBB disruption o

SUBMITTER: Leigh R 

PROVIDER: S-EPMC4955280 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature