A Worldwide Map of Plasmodium falciparum K13-Propeller Polymorphisms.

ABSTRACT:

Background

Recent gains in reducing the global burden of malaria are threatened by the emergence of Plasmodium falciparum resistance to artemisinins. The discovery that mutations in portions of a P. falciparum gene encoding kelch (K13)-propeller domains are the major determinant of resistance has provided opportunities for monitoring such resistance on a global scale.

Methods

We analyzed the K13-propeller sequence polymorphism in 14,037 samples collected in 59 countries in which malaria is endemic. Most of the samples (84.5%) were obtained from patients who were treated at sentinel sites used for nationwide surveillance of antimalarial resistance. We evaluated the emergence and dissemination of mutations by haplotyping neighboring loci.

Results

We identified 108 nonsy

SUBMITTER: Menard D 

PROVIDER: S-EPMC4955562 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature